Pimecrolimus CAS NO.137071-32-0

1.Pimecrolimus 2.White crystalline powder 3.Professional manufacture 4.High quality competitive price Description NamePimecrolimu…

1.Pimecrolimus2.White crystalline powder3.Professional manufacture4.High quality competitive price    Description   NamePimecrolimusAppearanceWhite crystalline powderCas   137071-32-0 MF     C43H68ClNO11Mol. mass810.4531GradeMedicine gradeAssay                   ≥99%PackageAluminum foil bag, drum     Pharmacology  Pimecrolimus is an ascomycin macrolactam derivative. It has been shown in vitro that pimecrolimus binds to macrophilin-12 and inhibits calcineurin. Thus pimecrolimus inhibits T-cell activation by inhibiting the synthesis and release of cytokines from T-cells. Pimecrolimus also prevents the release of inflammatory cytokines and mediators from mast cells.    General characteristics Pimecrolimus, like tacrolimus, belongs to the ascomycin class of macrolactam immunosuppressives, acting by the inhibition of T-cell activation by the calcineurin pathway and inhibition of the release of numerous inflammatory cytokines, thereby preventing the cascade of immune and inflammatory signals. Pimecrolimus has a similar mode of action to that of tacrolimus but is more selective, with no effect on dendritic (Langerhans) cells.It has lower permeation through the skin than topical steroids or topical tacrolimus although they have not been compared with each other for their permeation ability through mucosa. In addition, in contrast with topical steroids, pimecrolimus does not produce skin atrophy.It has been proven to be effective in various inflammatory skin diseases, e.g., seborrheic dermatitis,cutaneous lupus erythematosus, oral lichen planus, vitiligo,and psoriasis. Tacrolimus and pimecrolimus are both calcineurin inhibitors and function as immunosuppressants.    Contact information Gary RenZhengzhou Debao Fine Chemical co., ltdAddressRoom 305, Building 4, Jincheng International, Jingsan Road, Zhengzhou, China.Phone 86 0150 3800 2977Tel 0086 371 69123138     Picture show